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Is Spravato Ketamine Right for My Treatment-Resistant Depression?

6 min read

Deciding whether to take a new medication can be challenging, especially when the solution you’re considering is non-traditional or unconventional. Dealing with depression is tough, especially when you’ve tried nearly all the conventional treatments and still haven’t found the right solution. Spravato (esketamine) nasal spray is designed to provide the relief you’ve been seeking. Although it is a nontraditional medication and the method of administration is unconventional, it offers a potential solution for your needs. 

Now the question is: Is Spravato right for your treatment-resistant depression? We’re here to help you determine if it’s the right fit for you.

Spravato for Depression

Spravato is a prescription medication to treat adults who have been diagnosed with treatment-resistant depression (TRD) and adults who have been experiencing depressive symptoms and suicidal thoughts or actions from major depressive disorder (MDD). If you have tried two or more oral antidepressants without finding relief from your depression symptoms, you might be dealing with treatment-resistant depression (TRD). In such cases, Spravato could be a beneficial addition to your current oral antidepressant regimen. 

How it Works

There are some clinical studies that have shown that Spravato helps alleviate depressive symptoms by targeting different neural receptors in the brain. It specifically targets the N-methyl-D-aspartate (NMDA) receptor, which enhances brain plasticity through the stimulation of brain-derived neurotropic factor (BDNF) production and the activation of the mammalian target of rapamycin (mTOR). There is a study wherein the patients who continued using Spravato after 16 weeks of therapy experienced better outcomes compared to those who have discontinued the treatment. Moreover, the patients who were using Spravato have demonstrated a greater reduction in depressive symptoms than those who were treated with only a traditional oral antidepressant. 

Approval Status for Treatment-Resistant Depression

Spravato is the first and only approved medication shown to reduce depressive symptoms within 24 hours, offering a new option for rapid symptom relief until a longer-term treatment plan can be implemented. Spravato (esketamine) nasal spray was approved by the U.S. Food and Drug Administration (FDA) in 2019, to be used conjunction with an oral antidepressant, for the treatment of depression in adults who have not found relief with other antidepressant medications. With this approval, Spravato can be prescribed for: 

  • Adults who have been diagnosed with treatment-resistant depression (TRD), FDA-approved on March 5, 2019
  • Adults who have been diagnosed with major depressive disorder (MDD) experiencing acute suicidal ideation or behavior.

Considering Spravato for Your Treatment 

Spravato offers a unique approach as the only nasal spray treatment indicated for treatment-resistant depression (TRD). Nasal esketamine treatment is a relatively new method for treating depression, although esketamine has been used for anesthetic purposes for decades. It is primarily used to treat TRD and major depressive disorder with suicidal ideation (MDD), but it can also address other related behavioral issues. One of the most significant benefits reported by many patients using nasal esketamine is a noticeable improvement in mood. This rapid enhancement in mood can provide much-needed relief for those who have struggled to find success with traditional treatments.

Criteria for candidacy  

Spravato treatment is primarily recommended for patients who have been diagnosed with severe forms of depression, such as treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation. Psychiatrists often suggest this treatment when more conservative options have not been effective. For those who are ideal candidates for this kind of treatment, Spravato nasal esketamine can lead to a significant improvement in mood and help alleviate depressive thoughts. Moreover, it can also encourage increased physical activity, which is often diminished during periods of depression. This treatment offers hope for individuals who have not found relief through traditional antidepressant medications.

Benefits of Spravato treatment 

Spravato works differently than traditional antidepressants. While other medications usually take weeks or even months to start working, Spravato can provide its patients relief in just a matter of hours. This rapid onset of action can be life-changing for individuals who have been struggling with treatment-resistant depression for years. With its rapid relief, Spravato provides a more holistic and effective treatment solution for individuals who are struggling with depression. It can significantly improve mood and overall well-being, allowing patients to experience a faster and more comprehensive alleviation of their symptoms. Spravato nasal spray treatment also has some other benefits, such as:

  • Significant Improvement in Mood and Decreased Suicidal Thoughts
    Many individuals experience an uplift in their overall mood and well-being post-Spravato treatment. Alongside improved mood, Spravato also demonstrated effectiveness in diminishing persistent suicidal ideation, thereby enhancing overall mental health.
  • Ease of Use and Personalized Dosage
    Administered as a nasal spray, Spravato is convenient for individuals who struggle with swallowing pills. Moreover, with its tailored dosage, Spravato treatment also makes sure that its patients are able to receive the most effective depression management for their needs.
  • Minimal Side Effects and Long-lasting Results
    Many patients report minimal adverse effects from Spravato treatment, which makes it a comfortable and manageable option. Also, research indicates that the effects of Spravato treatment can last for weeks to months, providing sustained relief from depression symptoms.

Important Considerations Before Starting Spravato 

If conventional treatments prove ineffective, Spravato nasal esketamine treatment may offer relief for patients who are suffering from depression and its related symptoms. Though it has the ability to provide you with much-needed relief, here are some important considerations before starting Spravato (esketamine) for treatment-resistant depression:

  • Potential Side Effects and Monitoring Requirements
    Spravato may potentially lead to side effects such as dissociation, dizziness, nausea, vomiting, headache, and increased blood pressure. Patients must be monitored by a healthcare provider for at least 2 hours after each treatment session due to these potential risks. 
  • Risk of Misuse and Abuse
    Spravato is classified as a Schedule III controlled substance because of its potential for misuse. Your healthcare provider will carefully evaluate your risk of misuse before prescribing you with Spravato treatment.
  • Not a First-Line Treatment
    Spravato is specifically approved for treatment-resistant depression, indicating that other traditional medications have not provided relief. It is not typically prescribed as a first-line treatment.
  • Cost of Treatment
    Spravato can be quite expensive, and the insurance coverage for this treatment may vary. It is essential to discuss the potential financial implications of Spravato treatment with your healthcare provider before you go ahead and commit to this treatment.

Is Spravato Ketamine Right for Your Treatment-Resistant Depression?

Spravato (esketamine) could be a potential option for your treatment-resistant depression, but there’s some exploration needed to determine if it is the right fit. The most effective way to determine if Spravato nasal spray (esketamine) treatment is suitable for you is by consulting with a licensed psychiatrist. 

At Marpa Minds, we specialize in Spravato nasal esketamine treatment for individuals who are looking for ways to effectively cope with the symptoms of major depression or treatment-resistant depression. Our comprehensive evaluation will identify the most suitable course of action for your needs. Moreover, we encourage patients to ask questions and address any concerns they may have about the treatment process. Start your journey to recovery from depression with Marpa Minds, a New York City-based depression clinic focused on giving you the relief that you have been seeking. Get in touch with us today by contacting 1877-88-MARPA.