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Questions about Ketamine

What is ketamine?

Ketamine is an anesthetic that has been utilized by medical professionals and veterinarians since its legalization in 1970. Since the 1980s, ongoing research has explored ketamine’s potential for treating psychiatric disorders.
Ketamine acts by inhibiting the brain’s NMDA receptors and relieving the existential emotional burden experienced by the patient.

Is Ketamine a Psychedelic?

Psychedelic treatment, psychedelic therapy, or psychedelic-assisted psychotherapy involves using psychedelic substances like ketamine or psilocybin in controlled settings with trained professionals. It induces altered states of consciousness for therapeutic purposes, potentially aiding healing and personal growth. Research shows that it can effectively treat conditions like depression, anxiety, PTSD, and addiction.

Is ketamine safe?

Ketamine should only be used under professional medical supervision and according to prescribed dosage guidelines. Self-administration or misuse of ketamine can pose significant risks and may lead to adverse effects.

Is ketamine legal?

Yes, ketamine is legally available in all 50 states as a psychedelic option for medical purposes and has demonstrated effectiveness in treating depression.

Is ketamine therapy approved by the FDA?

The only FDA-approved ketamine therapy for Depression is Esketamine, also known as Spravato. It was introduced by Johnson and Johnson Pharmaceutical in 2019. At Marpa Minds,we only use the FDA-approved version of ketamine therapy.

What other psychedelics are legal for clinical use?

While psilocybin, and Ayahuasca/DMT are legal in some states, and MDMA is approved for clinical trials only, ketamine is currently the only psychedelic that is legal in all 50 states. Marpa Minds is on the forefront of providers that will be offering the future approved and insurance covered Psychedelics.

Questions about Spravato®

What is Spravato?

Spravato is the brand name for esketamine, a medication that is a derivative of ketamine. It is a nasal spray formulation of esketamine that was approved by the U.S. Food and Drug Administration (FDA) in 2019 for the treatment of treatment-resistant depression. Spravato is typically used in conjunction with an oral antidepressant for patients who have not responded adequately to other antidepressant treatments.

What sets apart Spravato from ketamine?

Both contain esketamine, a derivative of ketamine. However, Spravato is FDA-approved for treatment-resistant depression, administered as a nasal spray, while ketamine, used off-label for medical purposes, is commonly given intravenously. The nasal spray method makes Spravato more convenient, and it’s covered by insurance, unlike off-label ketamine.

What is the difference between Spravato and Esketamine?

Essentially, they’re the same thing: Spravato is the brand name for the nasal spray formulation of esketamine.
Esketamine is the active pharmaceutical ingredient, which is a form of ketamine that has been isolated and purified. Spravato, on the other hand, is a specific formulation of esketamine. It is a nasal spray that contains esketamine as its active ingredient.

How does Spravato differ from traditional antidepressants?

Spravato is specifically designed for treatment-resistant depression, utilized when standard antidepressants prove ineffective. Traditional antidepressants like SSRIs or SNRIs enhance neurotransmitter levels, e.g., serotonin or norepinephrine. In contrast, Spravato targets brain NMDA receptors, regulating glutamate activity, a mood-regulating factor.

How is Spravato administered?

Spravato is administered as a nasal spray. Your clinician will ensure you’re seated correctly. They will then show you how to insert the tip of the nasal spray device into one nostril, activate the nasal spray, and then repeat the process in the other nostril. You will then be monitored by the medical provider for the duration of the treatment, which is around 1.5 hours.

Can I receive Spravato if I’m currently on antidepressants?

Yes, Spravato is approved by the FDA to be taken in conjunction with oral antidepressants. It’s perfectly safe and recommended to take antidepressants and receive Spravato treatments!

What side effects can I expect from Spravato?

Not everyone experiences side effects. They last within an hour and fade naturally. Spravato’s mild sedation aids healing and promotes a disconnected feeling (dissociation) that fosters new neural connections. Marpa assists in processing this novel experience, leaving you joyful and grounded. Additional effects: dizziness, tiredness, nausea, mild/moderate headache, slight taste change. Temporary blood pressure/heart rate increases are monitored by our physicians.

Can Spravato cause any long-term side effects?

Current research does not indicate any negative long-term side effects for Spravato.

Is Spravato addictive?

When used properly under medical supervision as a treatment for approved indications, it is not addictive. However, individuals with a history of substance use disorder may be at higher risk of misusing Spravato. We’ll take a complete patient history before beginning treatment.

How likely is Spravato to be effective on TRD?

Success rate of Spravato on treatment-resistant depression is high. Clinical data indicates that 75% of people who receive Spravato treatment experience a positive response, and roughly half will experience complete remission.

Who should not take Spravato?

Individuals with untreated/unstable cardiovascular conditions, recent strokes, substance abuse history, certain medications (MAOIs), pregnancy/breastfeeding, and certain psychiatric conditions may be ineligible for Spravato (esketamine) treatments. Eligibility is determined by our healthcare professionals.

Can Spravato be taken at home?

Spravato must be administered in a REMS certified facility such as Marpa Minds, under the direction of a medical provider.

What is the difference between IV Ketamine and Spravato?

IV Ketamine:
Is not FDA-approved for the treatment of depression.
Is not covered by insurance.

Is FDA-approved for the treatment of depression.
Is covered by insurance.

At Marpa Minds, we prioritize the use of FDA-approved treatments like Spravato® to provide our patients with safe and effective options for the treatment of depression.

Questions about Getting Started

How is the Marpa Minds experience distinct from other ketamine clinics?

Our center boasts top-tier psychiatric providers for paramount clinical safety. Upon entering, you’ll encounter a serene, spa-like environment, meticulously designed to enhance your well-being.

What's the cost of Marpa Minds' ketamine treatment?

We focus on insurance-covered treatments to ensure mental health services’ accessibility for all.

Is a referral necessary to begin?

While not obligatory, having connected with your current mental health provider is beneficial. Collaboration optimizes your healing prospects.

How do I arrange an appointment?

Contact us here or call 1877-88-MARPA. We’re excited to connect with you!

What would disqualify me from Spravato Treatment?

Eligibility requires a depression diagnosis and trying at least 2 antidepressants.. An unfavorable history (aneurysms, heart/blood issues, hallucinatory disorders) may render you ineligible. We’ll evaluate your compatibility for safety.

Any additional information?

Appointments are around 2 hours; we can assist with post-treatment transportation. Protocol typically involves sessions twice weekly for the first month, reducing gradually for 3 months, then monthly for a year as maintenance.

Questions about Our Treatment

How long does each session take?

Sessions typically last about 2 hours. After administering Spravato®, we guide you through gentle breathwork, then monitor you. The effects of the medication wear off after approximately an hour and a half, at which point you’ll have the opportunity to relax in our private post-treatment lounge.

How soon will I feel the effects?

Most patients experience an immediate lift within 24 hours of receiving Spravato®. Generally, improvements in depression symptoms become noticeable within 4 weeks of starting treatments.

How many sessions are needed for permanent results?

Improvements are typically seen within about 4 weeks. The recommended protocol involves two sessions per week during the first month, followed by one session per week during the second month. Afterward, session frequency gradually decreases until remission is achieved.

Should I continue my therapy sessions alongside treatment?

Yes, it’s highly recommended to continue attending therapy sessions. While we’re here to support your healing, a network of mental health support often leads to the most successful outcomes.

What does the Spravato/ketamine therapy experience feel like?

Individual experiences vary, but common sensations include floating, euphoria, relaxation, and emotional responses. Some patients might feel nauseous, which we address. Positive Effects can last for varying periods, even days.

Can I drive myself home after a ketamine treatment?

No, it’s advised to avoid driving, operating heavy machinery, making important decisions, or engaging in risky activities until the day after treatment.

Is it recommended to bring someone with me to my appointment?

While optional, you’re welcome to bring a friend, loved one, or therapist if you’re comfortable. Our caring team provides emotional support throughout your session.

Questions about...


Questions about

Can I offer Spravato for my patients?

Providing Spravato treatment within your office may seem like an appealing option; however, there are several significant reasons why referring patients to a specialized treatment center like Marpa Minds is the more practical choice:

1. Prior Authorization: Obtaining prior authorization for Spravato treatments can be a complex and time-consuming process. Treatment centers have dedicated teams with extensive experience in navigating insurance requirements, ensuring a smoother approval process for your patients.

2. Treatment Planning: Effective Spravato treatment requires careful planning and monitoring. Treatment centers have the infrastructure to manage patient schedules, treatment sessions, and follow-up, ensuring the best outcomes for your patients.

3. Adequate Treatment Rooms: Adequate treatment rooms are essential to accommodate the Spravato administration and patient observation requirements. Marpa Minds is equipped with suitable facilities, providing a safe and comfortable environment for each patient.
5. REMS Protocol Compliance: The Risk Evaluation and Mitigation Strategy (REMS) for Spravato is stringent and necessitates adherence to specific safety protocols. Marpa Minds is well-versed in these guidelines, ensuring patient safety and compliance with
REMS requirements.
6. Insurance Access- you might be a Provider that does not take insurance or only participates in select Health Plans. Marpa aims to work with all insurance plans. This allows you to continue working with your client while allowing him to access the best
treatment for his condition.

If I want to refer a patient, how do I go about doing that?

Referring your patients to Marpa Minds for Spravato treatment is simple. Just contact our dedicated referral team at 877-88-MARPA or submit a referral on marpaminds/providers. We’ll take it from there, ensuring a smooth transition for your patients. Think of Marpa Minds as an extension of care for your patients.

What qualifications should my patients meet to be eligible for Spravato treatment?

To be eligible for Spravato treatment, your patients should have a diagnosis of treatment-resistant depression (TRD) and have tried at least two different oral antidepressant medications without sufficient improvement.

Who Oversees and Supports Patients During Their Spravato Treatment at Marpa Minds?

Our commitment to patient well-being is unwavering. Our centers are owned and directed by Board Certified Medical Doctors who ensure the highest standards of care. Patients undergo a thorough evaluation with psychiatric mental health providers to determine their eligibility for Spravato treatment.

Throughout the treatment sessions, patients are closely monitored by our dedicated psychiatric mental health providers who are trained in Ketamine Treatments to ensure their safety and comfort.

Moreover, what sets Marpa Minds apart is our unique approach to patient support. We offer support sitters who are trained in altered states of consciousness. These support sitters are instrumental in providing a safe, comfortable, and transformative experience for patients during their treatment. This additional level of care and personalized support ensures that patients have an amazing and positive experience throughout their Spravato treatment journey.

Are there any specific medical records or information I need to provide when referring a patient for Spravato treatment?

Yes, please briefly provide the patient’s history of depression treatment, previous medications used, and any other pertinent medical information. This will help our team assess their eligibility. Although this is not a requirement for treatment, it allows for a faster approval with the patient’s insurance plan. Our Psychiatric Providers do a full mental health evaluation to assess if a patient is fit for treatment.

Can I collaborate with Marpa Minds during my patient's Spravato treatment process?

Absolutely, collaboration is encouraged and will enhance the overall treatment experience for your patients. We value your input and can work closely with you to ensure coordinated care. Your patient’s well-being is our top priority.

What information should my patients expect to receive from Marpa Minds during their treatment journey?

Once your patients are referred to Marpa Minds, they will receive comprehensive information about the Spravato treatment process, what to expect during sessions, potential side effects, and how to prepare for each appointment. We strive to keep both you and your patients informed every step of the way.

Does Marpa Minds accept insurance for Spravato treatment?

Spravato is an insurance covered treatment, we work with all major insurance plans including Commercial, Tricare (VA), Medicare, & Medicaid. Our goal is to ensure that patients receive the care they need without financial barriers.

What support can Marpa Minds offer to me, as a medical provider, when referring patients for Spravato treatment?

Marpa Minds is dedicated to supporting medical providers throughout the referral and treatment process. We are available to address any questions or concerns you may have and can provide you with resources and information to help you make informed decisions about referring your patients for Spravato treatment. Please reach out to us by calling our texting line.

Can I schedule a consultation or visit Marpa Minds to learn more about the treatment process and facilities?

Absolutely, we welcome medical providers to visit our facility, meet our team, and learn more about the Spravato treatment process. You can schedule a consultation or arrange a visit by contacting our team at 914-222-0101 or emailing hello@marpaminds.com. We look forward to assisting you in any way we can.

What is the difference between IV Ketamine and Spravato?

IV Ketamine:
Is not FDA-approved for the treatment of depression.
Is not covered by insurance.

Is FDA-approved for the treatment of depression.
Is covered by insurance.

At Marpa Minds, we prioritize the use of FDA-approved treatments like Spravato® to provide our patients with safe and effective options for the treatment of depression.

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